Immune Cell population by sample

Table 1

Selected Immune Cell population by sample (line graph)

All Immune Cell population by sample (line graph)

Interpretation

Observations

• The T cell population shows a decrease across all treated samples when compared to the control, with the most significant reduction observed in CND3
  
• Macrophages (1), NK Cells, and Tregs all exhibit an increase in population across the treatments, with the largest increase occurring in CND3, except for NK Cells.
  
• Cancer cell populations remain relatively stable across treatments, though a slight increase is observed in CND3.

Interpretations

1. Suppressing T cell-mediated immune responses by this drug treatment.
   
2. A shift from a T cell-dominated response to a more varied immune response involving other cells that can engage in phagocytosis, immune regulation, and innate immunity.
   
3. CND3 exhibits a more synergistic effect compared to CND1.
   
4. This drug does not decrease the number of cancer cells; however, in CND3, the cancer cells might be weakened by the increased presence of macrophages and NK cells.

Possible follow-ups Questions

1. Identify factors that contribute to T cell suppression.
   
2. Identify factors that promote the increase of innate immune cells such as macrophages and NK cells.
   
3. Analyze changes in cancer cell characteristics between CTRL and CND3.