Professional summary


Experienced Senior Bioinformatics Scientist with a strong background in immunology and cancer biology research, specializing in leading bioinformatics projects from conception to completion. Extensive expertise in advanced NGS data integration, computational method design and cross-functional collaboration. Proven track record in delivering actionable insights to drive biological discovery, with first-author publications in Nature Immunology and Cell Reports. Skilled at coordinating multi-partner projects and managing pharmaceutical collaborations at Dana-Farber Cancer Institute. Recognized for exceptional analytical abilities and commitment to scientific understanding through innovative methodologies.

Sung Rye Park’s resume (pdf)


Data Analysis workflow Overview

  1. scRNA-seq pipeline
  2. RNA-seq pipeline
  3. ChIP-seq/Cut&Run/ATAC-seq pipeline
  4. Machine Learning application
  5. Public DB


Single Cell RNA-seq workflow




  • Initial Processing
    • CellRanger
    • Doublet Removals
    • Filtering by UMI and other parameters
  • UMAP and Clustering
  • Cluster-markers enrichment analysis
  • Cell type annotation
  • Population shift analysis
  • Integration (Harmony, CCA)
  • AUC
  • Imputation

Miscellaneous

Data_Processing in Linux env
WDL example
BCR-seq info (Antibody_discovery_Platform)
Basic Github usage
cellranger docker setup


Conference/Seminar Note

2024

   Conference Summary Report: 10X Genomics User Group Meeting 2024
   Conference Note : 2024 Festival in Genomics in Boston




Project Tracking Example





Public Pages

Github
LinkedIn

First/co-first authorship publications (pdf)

The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+ T cell fates. (Nature Immunology, 2024)
Single cell transcriptome analysis of colon cancer cell response to 5-fluorouracil-induced DNA damage (Cell Reports, 2020)
Holistic Characterization of Single Hepatocyte Transcriptome Responses to High Fat Diet (American Journal of Physiology-Endocrionlogy and Metabolism, 2020)



Bioinformatics Skills



Publications

Education



Last update: 2024-11-03